王旭  作物代谢调控与光生物学实验室主任

 邮箱：xu.wang@pku-iaas.edu.cn

 研究方向：（1）辣椒果实品质调控机理（2）植物RNA甲基化分子机制

个人简介 : 

        2007-2014  中国农业科学院，作物科学研究所，理学博士

        2014-2019  美国加州大学洛杉矶分校，分子、细胞及发育生物学系，博士后

        2019-2022  美国加州大学洛杉矶分校，分子、细胞及发育生物学系，助理项目科学家

        2022-至今  太阳成集团tyc7111cc，研究员

主要研究领域 : 

        辣椒（Capsicum spp.）是我国最重要的蔬菜作物之一，播种面积大，产值高，发展潜力巨大。本实验室主要围绕辣椒独特的天然产物，即辣椒素和辣椒红素的生物合成途径的生物化学和分子遗传调控机制开展基础和应用研究，并利用蛋白质定向进化等技术手段对辣椒素和辣椒红素合成途径重要的酶进行改造，为突破辣椒高辣度高色价育种瓶颈提供材料和理论基础。

       本实验室另一研究方向为N6-甲基腺苷（N6-Methyladenosine，简称m6A）RNA甲基化。m6A是真核细胞mRNA中含量最丰富的一种共价修饰，自上世纪70年代被发现以来，关于其分子机制的研究直到近年来才取得了较大的进展，并逐渐成为当今表观遗传研究领域的前沿热点。m6A修饰能够广泛影响RNA几乎所有的代谢过程，如剪接、ployA位点选择、出核、降解和翻译等。m6A RNA修饰具有非常重要的生理功能，其水平异常与多种人类重大疾病相关，如肥胖、糖尿病、自免疫病、神经退行性疾病和癌症等。m6A RNA甲基化在植物和作物中的研究刚刚起步，许多重要的理论问题尚待解答。本实验将在前期研究结果的基础上探索并挖掘植物RNA甲基化途径背后未知的分子生物学机制。

发表论文 : 

        1.   Liu, S.*, Zhang, L.*, Hu, X., Chen, Y., Zhang, S., Zhao, Q., Bie, Y., Wang, X.^# and Wang, Q.^# (2022). Differential photoregulation of the nuclear and cytoplasmic CRY1 in Arabidopsis. New Phytologist. 234: 1332-1346. (^# 共同通讯作者)

        2.   Wang, X.*, Jiang, B.*, Gu, Lianfeng.*, Chen, Y., Mora, M., Zhu, M., Noory, E., Wang, Q.^# and Lin, C.^# (2021). A photoregulatory mechanism of the circadian clock in Arabidopsis. Nature Plants. 7: 1397.

        3.   Cheng, Z., Zhang, X., Huang, P., Huang, G., Zhu, J., Chen, F., Miao, Y., Liu, L., Fu, Y-F^#. and Wang, X.^# (2020). Nup96 and HOS1 are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-day Photoperiodic Flowering Regulation in Arabidopsis. Plant Cell. 32: 374 (^# 通讯作者)

        4.   Wang, X., Wang, Q., Han, Y.-J., Liu, Q., Gu, L., Yang, Z., Su, J., Liu, B., Zuo, Z., He, W., Wang, J., Liu, B., Matsui, M., Kim, J.-I., Oka, Y. and Lin, C. (2017). A CRY-BIC negative-feedback circuitry regulating blue light sensitivity of Arabidopsis. Plant Journal, 92: 426.

        5.   Wang, Q*., Zuo Z.*, Wang, X.*, Gu, L., Yoshizumi, T., Yang, Z., Yang, L., Liu, Q., Liu W., Han, Y., Liu B., Wohlschlegel, J., Matsui, M., Oka, Y. and Lin, C. (2016). Photoactivation and inactivation of Arabidopsis cryptochrome 2. Science. 354: 343. (*共同第一作者)

        6.   Gao, J.*, Wang, X.*, Zhang, M., Bian, M., Deng, W., Zuo, Z., Yang, Z., Zhong, D., and Lin, C. (2015). Trp triad-dependent rapid photoreduction is not required for the function of Arabidopsis CRY1. Proceedings of the National Academy of Sciences USA, 112: 9135. (*共同第一作者)

        7.   Yang, L.*, Wang, X.*, Deng, W., Mo, W., Liu, Q., Zhang, C., Wang, Q., Lin, C and Zuo, Z. (2016). Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Frontiers in Plant Science, 7:940. (*共同第一作者)

        8.   Wang, X., Fan, C., Zhang, X., Zhu, J. and Fu, Y. (2013). BioVector, a flexible system for gene specific-expression in plants. BMC Plant Biology, 13:198.

        9.   Fan, C.*, Wang, X.*, Wang, Y., Hu, R., Zhang, X., Chen, J. and Fu, Y. (2013). Genome-Wide Expression Analysis of Soybean MADS Genes Showing Potential Function in the Seed Development. PLoS ONE, 8: e62288. (*共同第一作者)

     10.   Wang, Q.*, Liu, Q.*, Wang, X., Zuo Z., Oka, Y. and Lin, C. (2018). New insights into the mechanisms of phytochrome-cryptochrome coaction. New Phytologist, 217: 547.

       11.  Wang, Q., Zuo, Z., Wang, X., Liu, Q., Gu, L., Oka, Y. and Lin, C. (2018). Beyond the photocycle — how cryptochromes regulate photoresponses in plants. Current Opinion in Plant Biology, 45:120

       12.  Liu, L.*, Jiang, Y. *, Zhang, X. *, Wang, X., Wang, Y., Han, Y., Coupland, G., Jin, J., Searle, I., Fu Y. and Chen, F. (2017). Two SUMO Proteases SUMO PROTEASE RELATED TO FERTILITY1 and 2 Are Required for Fertility in Arabidopsis. Plant Physiology, 175:1703.

       13.  Liu, Q., Wang Q., Deng W., Wang X., Piao M., Cai D., Li Y., Barshop W., Yu X., Zhou T., Liu B., Oka Y., Wohlschlegel J., Zuo Z. and Lin C. (2017). Molecular basis for blue light-dependent phosphorylation of Arabidopsis cryptochrome 2. Nature Communications. 8: 15234. 

       14.  Liu, Q., Wang, Q., Liu, B., Wang, W., Wang, X., Park, J., Yang, Z., Du, X., Bian, M. and Lin, C. (2016). The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases. Plant & Cell Physiology, 57: 2175

      15.  Li, Q., Fan, C., Zhang, X., Wang, X., Wu, F., Hu, R. and Fu, Y. (2014). Identification of a Soybean MOTHER OF FT AND TFL1 Homolog Involved in Regulation of Seed Germination. PLoS ONE, 9: e99642.

      16.  Fan, C., Hu, R., Zhang, X., Wang, X., Zhang, W., Zhang, Q., Ma, J. and Fu, Y. (2014) Conserved CO-FT regulons contribute to the photoperiod flowering control in soybean. BMC Plant Biology. 14:9.

      17.  Fan, C., Wang, X., Hu, R., Wang, Y., Xiao, C., Jiang, Y., Zhang, X., Zheng, C. and Fu, Y. (2013) The pattern of Phosphate transporter 1 genes evolutionary divergence in Glycine max L. BMC Plant Biology.13:48.

      18.  Wang, X.^#, Liu, Q., He, W., Lin, C. and Wang, Q^#. (2019). Characterization of Flowering Time Mutants. In: Hiltbrunner A. (eds) Phytochromes. Methods in Molecular Biology, vol 2026. Humana, New York, NY. (书籍章节；^# 通讯作者)

      19.  Wang, X. ^#, Wang, Q., Nguyen, P. and Lin, C. (2014). Cryptochrome-mediated light responses in plants.  35:167-89. (书籍章节； ^# 通讯作者)