钱伟强 作物表观遗传研究组客座研究员
邮箱：wqqian@pku.edu.cn
研究方向：植物表观遗传与逆境响应
个人简介：
教育经历：
1998.9-2002.7 北京师范大学，生物学，理学学士
2002.9-2007.7 中国科学院遗传与发育生物学研究所，遗传学，理学博士
2006.11-2007.5 加拿大女皇大学，访问学者
工作经历：
2007.7-2009.4 美国康奈尔大学，博士后
2009.5-2010.12 美国加州大学河滨分校，博士后
2011.1-2011.12 美国普渡大学，博士后
2012.1-2013.6 中国科学院上海植物逆境生物学研究中心，青年研究员
2013.7-2021.7 北京大学生命科学院，北大-清华生命联合中心，研究员
2021.7 – 至今 北京大学现代农学院，太阳成集团tyc7111cc，研究员
主要荣誉：
国家自然基金委“优秀青年基金”获得者
研究工作：
以拟南芥和水稻等为模式植物，综合运用遗传学、生物化学和细胞生物学的方法，对植物体内表观遗传的分子机制和生物学功能进行深入的研究。主要研究方向包括：1、植物基因组DNA主动去甲基化的分子机制和生物学功能；2、植物基因沉默的表观遗传学机制和生物学功能；3、植物响应周围环境的表观遗传机制。
研究成果：
近年来在植物表观遗传领域取了一系列基础研究成果：鉴定了一个调控去甲基化酶ROS1招募的IDM1蛋白复合体，阐明了ROS1招募的分子机制；解析了DNA主动去甲基化的酶学机制，揭示了DNA主动去甲基化在植物维管分化过程中的重要功能；解析了植物响应逆境的表观遗传机制。在Science Advances、Nature Communications、Nature Plants、Plant Cell、Molecular Plant等国际主流刊物上发表了SCI论文40多篇，其中通讯作者15篇(包括2篇Science Advances、1篇Nature Plants、1篇Nature Communications、1篇Cell Host & Microbe、2篇Plant Cell、1篇Molecular Plant)，第一作者或共同第一作者7篇(包括1篇Science、2篇Molecular Cell和1篇Plant Cell)。
代表性论文:（*共同第一作者, # 通讯作者）：
1. Wang Y. *, Liu Y. *, Qu S., Liang W., Sun L., Ci D., Ren Z., Fan L-M., and Qian W. # (2022) Nitrogen starvation induces genome-wide activation of transposable elements in Arabidopsis. J. Integr. Plant Biol. doi: 10.1111/jipb.13376
2. Cao Y., Wang J., Wu S., Yin X., Shu J., Dai X., Liu Y., Sun L., Zhu D., Deng X.W., Ye K., and Qian W.# (2022) The small nucleolar RNA SnoR28 regulates plant growth and development by directing rRNA maturation. Plant Cell, 34, 4173-4190.
3. Liu N.*, Xu Y.*, Li Q., Cao Y., Yang D., Liu S, Wang X, Mi Y., Liu Y, Ding C., Liu Y., Tuan YW., Gao G., Chen J.#, Qian W.#, and Zhang X.# (2022) A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. Cell Host Microbe, 30, 1124-1138.
4. Tong J.*, Ren Z.*, Sun L.*, Zhou S., Yuan W., Hui Y., Ci D., Wang W., Fan L-M., Wu Z., and Qian W. # (2022) ALBA proteins confer thermotolerance through stabilizing HSF mRNAs in cytoplasmic granules. Nat. Plants, 8, 778-791.
5. Li J.*, Liang W.*, Liu Y., Ren Z., Ci D., Chang J., and Qian W.# (2022) The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates. Plant Cell, 34, 852-866.
6. Liang W.*, Li J.*, Sun L.*, Liu Y., Lan Z., and Qian W.# (2022) Deciphering the synergistic and redundant roles of CG and non-CG DNA methylation in plant development and TE silencing. New Phytol. 233, 722-737.
7. Lin W.*, Sun L.*, Huang R., Liang W., Liu X., He H., Fukuda H., He X.Q.#, and Qian W.# (2020) Active DNA demethylation regulates tracheary element differentiation in Arabidopsis. Sci. Adv. 6, eaaz963.
8. Sun L.*, Jing Y.*, Liu X.*, Li Q.*, Xue Z., Cheng Z., Wang D., He H.#, and Qian W.# (2020) Heat stress-induced transposon activation correlates with 3D chromatin organization rearrangement in Arabidopsis. Nat. Commun. 11(1):1886. doi: 10.1038/s41467-020-15809-5.
9. Yuan, W.*, Zhou, J.*, Tong, J.*, Zhuo, W., Wang, L., Li, Y., Sun, Q.#, and Qian, W.# (2019). ALBA protein complex reads genic R-loops to maintain genome stability in Arabidopsis. Sci. Adv. 5, eaav9040.
10. Wang, X., Chen, X., Sun, L., and Qian, W. # (2019). Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis. PLoS Genet. 15, e1008094.
11. Li, J.*, Liang, W.*, Li, Y., and Qian, W. # (2018). APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE play overlapping roles in the maintenance of epigenome and genome stability. Plant Cell 30, 1954-1970.
12. Li, Y.*, Kumar, S.*, and Qian, W.# (2018). Active DNA demethylation: mechanism and role in plant development. Plant Cell Rep. 37, 77-85.
13. Jing, Y. *, Sun, H. *, Yuan, W., Wang, Y., Li, Q., Liu, Y., Li, Y., and Qian, W. # (2016). SUVH2 and SUVH9 couple two essential steps for transcriptional gene silencing in Arabidopsis. Mol. Plant 9, 1156-1167.
14. Wang, X.*, Li, Q.*, Yuan, W., Cao, Z., Qi, B., Kumar, S., Li, Y., and Qian, W. # (2016). The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation. Sci. Rep. 6, 26443.
15. Li, Q.*, Wang, X.*, Sun, H., Zeng, J., Cao, Z., Li, Y., and Qian, W. # (2015). Regulation of active DNA demethylation by a Methyl-CpG-Binding domain protein in Arabidopsis thaliana. PLoS Genet. 11, e1005210.
16. Qian, W.*, Miki, D.*, Lei, M.*, Zhu, X., Zhang, H., Liu, Y., Li, Y., Lang, Z., Wang, J., Tang, K., Liu. R., and Zhu. J.K. (2014). Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis. Mol. Cell 55, 361-371.
17. Qian, W.*, Miki, D.*, Zhang, H., Liu, Y., Zhang, X., Tang, K., Kan, Y., La, H., Li, X., Li, S., Zhu. X., Shi. X., Zhang. K., Pontes. O., Chen. X., Liu. R., Gong. Z., and Zhu. J.K. (2012). A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science 336, 1445-1448.